ABSTRACT
Context (Background): Periodontitis is an infectious inflammatory disease with increase in salivary Nitric oxide levels and Curcumin is known to inhibit inflammatory mediators and neutralize nitric oxide which is expressed in salivary glands. To evaluate and compare the possible improvement in parameters of periodontal disease and salivaryAim: nitric oxide levels in patients undergoing scaling and root planing (SRP) alone and scaling and root planing (SRP) with systemic curcumin administration. In one group, systemic curcumin will be administered along withSettings & Design: SRP & in another group only SRP will be performed. In Group A, SRP along with systemicMethods & Materials: curcumin was administered, and in Group B only SRP was performed. In both the groups, periodontal parameters such as the plaque Index (PI), gingival index (GI), probing pocket depth (PPD), clinical attachment level (CAL), presence or absence of bleeding on probing (BOP) and salivary nitric oxide (NO) levels by spectrophotometer were assessed at baseline and after three month. Chi-Square-test was used so as to evaluate and compare theStatistical Analysis used: possible improvement in parameters of periodontal disease and salivary nitric oxide levels in patients undergoing scaling and root planing (SRP) alone and scaling and root planing (SRP) with systemic curcumin administration. Results & Conclusions: Clinically significant results with improvement in clinical parameters and reduction in salivary NO levels were noticed in both the groups, although test group showed more reduction in the salivary NO levels when compared to the control group thus concluding that administration of systemic curcumin is effective against salivary NO levels and can be used as an adjunct to SRP.
ABSTRACT
Background: Aim: To assess prevalence pattern of cleft lip and palate and to assess the etiological risk factors like history of consanguinity, familial tendency and socio – economic status in children with cleft lip and/or palate. Methods:Case records (N=821) of patients with cleft lip and palate were accessed to collect the data. The following information was collected: Age, Gender, Education, Occupation and Income of the parent, History of consanguinity, Familial tendency and Chief complaint/s. The SPSS software was used for the statistical analysis to do the chi-square test and significance level adopted was 5% (P < 0.05). Results: Orofacial clefting was more common in males and laterality of cleft lip occurred more on the left side. The familial tendency was present only in 3% cases. The history of consanguinity was present in 35.7% cases. The socio – economic deprivation was prominent in cleft cases and values depicted statistical significance. Conclusion: Higher risk of orofacial clefting was seen in consanguineous relations and in families with socio – economic deprivation